Aurora 3D Barcode Generator serial number is very popular all over the world. Serial number generator for aurora 3d barcode generator serial number is..Role of cytokeratin in the neuroendocrine tumor of the appendix.
Neuroendocrine neoplasms of the appendix are uncommon tumors of both the adult and the pediatric age groups. For their malignant behavior, prognostic significance and therapeutic outcome, cytokeratin analysis may be a valuable adjunct to the diagnostic methods in that it allows for better classification of these tumors according to their cell differentiation and genetic characteristics. We present a neuroendocrine tumor of the appendix in a 51-year-old male. The clinical and histologic features of this tumor were similar to those reported in the literature. Cytokeratin expression was determined by immunocytochemistry using a monoclonal antibody (CK AE1/AE3). Staining was observed in the vast majority of neoplastic cells in both the individual sheets and in the tumor masses, but a continuous linear pattern of staining was not seen. The tumor was also investigated for the presence of the c-erbB-2 oncogene by immunocytochemistry and by the Southern blot method. A number of antibodies were used. Immunocytochemistry with anti-HER2/neu and anti-EGFR antibodies gave negative results. The tumor cells were negative for c-erbB-2 by immunocytochemistry and by the Southern blot method. Immunocytochemistry with the MAb Ck 8.12, which recognizes epitopes of keratin K8, K19, and K40, was positive. The expression of cytokeratin by the tumor cells in this neuroendocrine neoplasm indicates that this tumor is a well-differentiated carcinoma. The presence of keratin in the tumor cells may also imply a particular behavior of these tumors, since the expression of cytokeratin may be related to their neural origin. 0b46394aab